Improved performance of epidemiologic and genetic risk models for rheumatoid arthritis serologic phenotypes using family history.

ABSTRACT:

Objective

To develop and validate rheumatoid arthritis (RA) risk models based on family history, epidemiologic factors and known genetic risk factors.

Methods

We developed and validated models for RA based on known RA risk factors, among women in two cohorts: the Nurses' Health Study (NHS, 381 RA cases and 410 controls) and the Epidemiological Investigation of RA (EIRA, 1244 RA cases and 971 controls). Model discrimination was evaluated using the area under the receiver operating characteristic curve (AUC) in logistic regression models for the study population and for those with positive family history. The joint effect of family history with genetics, smoking and body mass index (BMI) was evaluated using logistic regression models to estimate ORs for RA.

Results

The

SUBMITTER: Sparks JA 

PROVIDER: S-EPMC4262726 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature