Meta-eQTL: a tool set for flexible eQTL meta-analysis.

ABSTRACT:

Background

Increasing number of eQTL (Expression Quantitative Trait Loci) datasets facilitate genetics and systems biology research. Meta-analysis tools are in need to jointly analyze datasets of same or similar issue types to improve statistical power especially in trans-eQTL mapping. Meta-analysis framework is also necessary for ChrX eQTL discovery.

Results

We developed a novel tool, meta-eqtl, for fast eQTL meta-analysis of arbitrary sample size and arbitrary number of datasets. Further, this tool accommodates versatile modeling, eg. non-parametric model and mixed effect models. In addition, meta-eqtl readily handles calculation of chrX eQTLs.

Conclusions

We demonstrated and validated meta-eqtl as fast and comprehensive tool to meta-analyze multiple datasets and Ch

SUBMITTER: Di Narzo AF 

PROVIDER: S-EPMC4262975 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature