Methylomic profiling of human brain tissue supports a neurodevelopmental origin for schizophrenia.

ABSTRACT:

Background

Schizophrenia is a severe neuropsychiatric disorder that is hypothesized to result from disturbances ine arly brain development. There is mounting evidence to support a role for developmentally regulated epigenetic variation in the molecular etiology of the disorder. Here, we describe a systematic study of schizophrenia-associated methylomic variation in the adult brain and its relationship to changes in DNA methylation across human fetal brain development.

Results

We profile methylomic variation in matched prefrontal cortex and cerebellum brain tissue from schizophrenia patients and controls, identifying disease-associated differential DNA methylation at multiple loci,particularly in the prefrontal cortex, and confirming these differences in an independent set of

SUBMITTER: Pidsley R 

PROVIDER: S-EPMC4262979 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature