Impulsivity and comorbid traits: a multi-step approach for finding putative responsible microRNAs in the amygdala.

ABSTRACT: Malfunction of synaptic plasticity in different brain regions, including the amygdala plays a role in impulse control deficits that are characteristics of several psychiatric disorders, such as ADHD, schizophrenia, depression and addiction. Previously, we discovered a locus for impulsivity (Impu1) containing the neuregulin 3 (Nrg3) gene, of which the level of expression determines levels of inhibitory control. MicroRNAs (miRNAs) are potent regulators of gene expression, and have recently emerged as important factors contributing to the development of psychiatric disorders. However, their role in impulsivity, as well as control of Nrg3 expression or malfunction of the amygdala, is not well established. Here, we used the GeneNetwork database of BXD mice to search for correlated traits with i

SUBMITTER: Pietrzykowski AZ 

PROVIDER: S-EPMC4263087 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature