Joint analysis of differential gene expression in multiple studies using correlation motifs.

ABSTRACT: The standard methods for detecting differential gene expression are mostly designed for analyzing a single gene expression experiment. When data from multiple related gene expression studies are available, separately analyzing each study is not ideal as it may fail to detect important genes with consistent but relatively weak differential signals in multiple studies. Jointly modeling all data allows one to borrow information across studies to improve the analysis. However, a simple concordance model, in which each gene is assumed to be differential in either all studies or none of the studies, is incapable of handling genes with study-specific differential expression. In contrast, a model that naively enumerates and analyzes all possible differential patterns across studies can deal with s

SUBMITTER: Wei Y 

PROVIDER: S-EPMC4263229 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature