Concerted bioinformatic analysis of the genome-scale blood transcription factor compendium reveals new control mechanisms.

ABSTRACT: Transcription factors play a key role in the development of a disease. ChIP-sequencing has become a preferred technique to investigate genome-wide binding patterns of transcription factors in vivo. Although this technology has led to many important discoveries, the rapidly increasing number of publicly available ChIP-sequencing datasets still remains a largely unexplored resource. Using a compendium of 144 publicly available murine ChIP-sequencing datasets in blood, we show that systematic bioinformatic analysis can unravel diverse aspects of transcription regulation; from genome-wide binding preferences, finding regulatory partners and assembling regulatory complexes, to identifying novel functions of transcription factors and investigating transcription dynamics during development.

SUBMITTER: Joshi A 

PROVIDER: S-EPMC4263230 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature