Natural CMT2 variation is associated with genome-wide methylation changes and temperature seasonality.

ABSTRACT: As Arabidopsis thaliana has colonized a wide range of habitats across the world it is an attractive model for studying the genetic mechanisms underlying environmental adaptation. Here, we used public data from two collections of A. thaliana accessions to associate genetic variability at individual loci with differences in climates at the sampling sites. We use a novel method to screen the genome for plastic alleles that tolerate a broader climate range than the major allele. This approach reduces confounding with population structure and increases power compared to standard genome-wide association methods. Sixteen novel loci were found, including an association between Chromomethylase 2 (CMT2) and temperature seasonality where the genome-wide CHH methylation was different for the group of

SUBMITTER: Shen X 

PROVIDER: S-EPMC4263395 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature