Rs833061 and rs699947 on promoter gene of vascular endothelial growth factor (VEGF) and associated lung cancer susceptibility and survival: a meta-analysis.

ABSTRACT:

Background

As 2 important SNPs located in the promoter region of VEGF gene, the roles of rs833061 (-460C>T) and rs699947 (-2578C>A) in lung cancer susceptibility and survival remain inconclusive and controversial.

Material/methods

For better understanding of these 2 SNPs in lung cancer risk and survival, a meta-analysis was performed to pool findings of previous studies and to generate large-scale evidence.

Results

Based on the 10 eligible studies included, this study observed that the -460C>T polymorphism generally had no significant effect on lung cancer risk. However, subgroup analysis found that -460TT homozygote variant might confer significantly increased cancer risk for Asians (TT vs. CC: OR=1.69, 95% CI 1.08-2.63, p=0.02), but not in Caucasians. Similar result

SUBMITTER: Tu J 

PROVIDER: S-EPMC4263404 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature