Stratified pathway analysis to identify gene sets associated with oral contraceptive use and breast cancer.

ABSTRACT: Cancer biomarker discovery can facilitate drug development, improve staging of patients, and predict patient prognosis. Because cancer is the result of many interacting genes, analysis based on a set of genes with related biological functions or pathways may be more informative than single gene-based analysis for cancer biomarker discovery. The relevant pathways thus identified may help characterize different aspects of molecular phenotypes related to the tumor. Although it is well known that cancer patients may respond to the same treatment differently because of clinical variables and variation of molecular phenotypes, this patient heterogeneity has not been explicitly considered in pathway analysis in the literature. We hypothesize that combining pathway and patient clinical information

SUBMITTER: Pang H 

PROVIDER: S-EPMC4263464 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature