Quantitative susceptibility mapping of multiple sclerosis lesions at various ages.

ABSTRACT:

Purpose

To assess multiple sclerosis (MS) lesions at various ages by using quantitative susceptibility mapping (QSM) and conventional magnetic resonance (MR) imaging.

Materials and methods

Retrospectively selected were 32 clinically confirmed MS patients (nine men and 23 women; 39.3 years ± 10.9) who underwent two MR examinations (interval, 0.43 years ± 0.16) with three-dimensional gradient-echo sequence from August 2011 to August 2012. To estimate the ages of MS lesions, MR examinations performed 0.3-10.6 years before study examinations were studied. Hyperintensity on T2-weighted images was used to define MS lesions. QSM images were reconstructed from gradient-echo data. Susceptibility of MS lesions and temporal rates of change were obtained from QSM images. Lesion suscepti

SUBMITTER: Chen W 

PROVIDER: S-EPMC4263629 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature