Multimodality imaging to assess immediate response to irreversible electroporation in a rat liver tumor model.

ABSTRACT:

Purpose

To compare changes on ultrasonographic (US), computed tomographic (CT), and magnetic resonance (MR) images after irreversible electroporation (IRE) ablation of liver and tumor tissues in a rodent hepatoma model.

Materials and methods

Studies received approval from the institutional animal care and use committee. Forty-eight rats were used, and N1-S1 tumors were implanted in 24. Rats were divided into groups and allocated for studies with each modality. Imaging was performed in normal liver tissues and tumors before and after IRE. MR imaging was performed in one group before and after IRE after hepatic vessel ligation. US images were graded to determine echogenicity changes, CT attenuation was measured (in Hounsfield units), and MR imaging signal-to-noise ratio (SNR)

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC4263650 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature