Effect of diabetes on brain structure: the action to control cardiovascular risk in diabetes MR imaging baseline data.

ABSTRACT:

Purpose

To investigate the association of characteristics of type 2 diabetes mellitus (duration and biochemical severity of diabetes) to brain structure measured on magnetic resonance (MR) images, specifically testing whether more severity in metrics of diabetes is inversely correlated with brain volumes and positively correlated with ischemic lesion volumes.

Materials and methods

This study protocol was approved by the institutional review board of each center and participants provided written informed consent. Baseline severity of diabetes was evaluated by testing fasting plasma glucose levels, hemoglobin A1c levels, and duration of diabetes. MR imaging was performed with fluid-attenuated inversion recovery, proton-density, T2-weighted, and T1-weighted sequences, which wer

SUBMITTER: Bryan RN 

PROVIDER: S-EPMC4263658 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature