Vitamin D status is associated with mortality, morbidity, and growth failure among a prospective cohort of HIV-infected and HIV-exposed Tanzanian infants.

ABSTRACT:

Background

Vitamin D is a potent immunomodulator, but its impact on morbidity and mortality among infants remains unclear.

Objective

The objective of the study was to prospectively assess the association of vitamin D status with mortality, morbidity, and growth during the first 2 y of life.

Methods

A prospective cohort of 253 HIV-infected and 948 HIV-exposed Tanzanian infants enrolled in a randomized trial of multivitamins (not including vitamin D) was studied. Serum 25-hydroxyvitamin D [25(OH)D] concentrations were measured at 5-7 wk of age and infants were followed at monthly clinic visits until 24 mo. Physicians performed a clinical exam every 3 mo or when an illness was noted.

Results

Serum 25(OH)D concentrations were (means ± SDs) 18.6 ± 10.3 ng/mL and 18.

SUBMITTER: Sudfeld CR 

PROVIDER: S-EPMC4264018 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature