Derivation and validation of homocysteine score in u.s. Men and women.

ABSTRACT:

Background

One-carbon metabolism, which is crucial in DNA synthesis and genomic stability, is an interrelated network of biochemical reactions involved in several dietary and lifestyle factors. The development of the homocysteine score using these factors may be useful to reflect the status of one-carbon metabolism in large epidemiologic studies without biologic samples to measure homocysteine directly.

Objective

The aim of this study was to develop an homocysteine score that reflects one-carbon metabolism better than individual dietary or lifestyle factors.

Methods

We divided 2023 participants with measured plasma total homocysteine data in the Nurses' Health Study and the Health Professionals Follow-Up Study into training (n = 1619) and testing (n = 404) subsets. Us

SUBMITTER: Jung S 

PROVIDER: S-EPMC4264025 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature