Mixed pro- and anti-oxidative effects of pomegranate polyphenols in cultured cells.

ABSTRACT: In recent years, the number of scientific papers concerning pomegranate (Punica granatum L.) and its health properties has increased greatly, and there is great potential for the use of bioactive-rich pomegranate extracts as ingredients in functional foods and nutraceuticals. To translate this potential into effective strategies it is essential to further elucidate the mechanisms of the reported bioactivity. In this study HepG2 cells were supplemented with a pomegranate fruit extract or with the corresponding amount of pure punicalagin, and then subjected to an exogenous oxidative stress. Overall, upon the oxidative stress the gene expression and activity of the main antioxidant enzymes appeared reduced in supplemented cells, which were more prone to the detrimental effects than unsuppleme

SUBMITTER: Danesi F 

PROVIDER: S-EPMC4264122 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature