Pilot study of cytological testing for oesophageal squamous cell dysplasia in a high-risk area in Northern Iran.

ABSTRACT:

Background

Oesophageal squamous cell carcinoma (ESCC) is a fatal disease with 5-year survival rates of <5% in Northern Iran. Oesophageal squamous dysplasia (ESD) is the precursor histologic lesion of ESCC. This pilot study was conducted to assess the feasibility, safety, and acceptability of non-endoscopic cytological examination of the oesophagus and to provide initial data on the accuracy of cytological atypia for identifying patients with ESD in this very-high-risk area.

Methods

Randomly selected asymptomatic participants of the Golestan Cohort Study were recruited. A cytological specimen was taken using a capsule sponge device and evaluated for atypical cells. Sections of the cytological specimen were also stained for p53 protein. Patient acceptability was assessed using

SUBMITTER: Roshandel G 

PROVIDER: S-EPMC4264437 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature