Modelling childhood growth using fractional polynomials and linear splines.

ABSTRACT:

Background

There is increasing emphasis in medical research on modelling growth across the life course and identifying factors associated with growth. Here, we demonstrate multilevel models for childhood growth either as a smooth function (using fractional polynomials) or a set of connected linear phases (using linear splines).

Methods

We related parental social class to height from birth to 10 years of age in 5,588 girls from the Avon Longitudinal Study of Parents and Children (ALSPAC). Multilevel fractional polynomial modelling identified the best-fitting model as being of degree 2 with powers of the square root of age, and the square root of age multiplied by the log of age. The multilevel linear spline model identified knot points at 3, 12 and 36 months of age.

Result

SUBMITTER: Tilling K 

PROVIDER: S-EPMC4264511 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature