A novel role for SIRT-1 in L-arginine protection against STZ induced myocardial fibrosis in rats.

ABSTRACT:

Background

L-arginine (L-ARG) effectively protects against diabetic impediments. In addition, silent information regulator (SIRT-1) activators are emerging as a new clinical concept in treating diabetic complications. Accordingly, this study aimed at delineating a role for SIRT-1 in mediating L-ARG protection against streptozotocin (STZ) induced myocardial fibrosis.

Methods

Male Wistar rats were allocated into five groups; (i) normal control rats received 0.1 M sodium citrate buffer (pH 4.5); (ii) STZ at the dose of 60 mg/kg dissolved in 0.1 M sodium citrate buffer (pH 4.5); (iii) STZ + sirtinol (Stnl; specific inhibitor of SIRT-1; 2 mg/Kg, i.p.); (iv) STZ + L-ARG given in drinking water (2.25%) or (v) STZ + L-ARG + Stnl.

Results

L-ARG increased myocardial SIRT-1 expr

SUBMITTER: Rizk SM 

PROVIDER: S-EPMC4264750 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature