The clinical significance of DC-SIGN and DC-SIGNR, which are novel markers expressed in human colon cancer.

ABSTRACT:

Background

Colon cancer has always been diagnosed at a late stage, which is associated with poor prognosis. The currently used serum tumor markers CEA and CA19-9 display low sensitivity and specificity and may not have diagnostic value in early stage colon cancer. Thus, there is an urgent need to identify novel serum biomarkers for use in the early detection of colon cancer.

Methods

In this study, the expression of DC-SIGN and DC-SIGNR in serum was detected by enzyme-linked immunosorbent assay (ELISA). DC-SIGN and DC-SIGNR expression was detected in cancer tissues by immunohistochemistry (IHC).

Results

The level of sDC-SIGN was lower in patients than in the healthy controls, while the level of sDC-SIGNR in patients was higher than in the healthy controls. Both sDC-SIG

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC4264775 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature