Arsenic exposure, telomere length, and expression of telomere-related genes among Bangladeshi individuals.

ABSTRACT:

Background

Inorganic arsenic is a carcinogen whose mode of action may involve telomere dysfunction. Recent epidemiological studies suggest that chronic arsenic exposure is associated with longer telomeres and altered expression of telomere-related genes in peripheral blood. In this study, we evaluated the association of urinary arsenic concentration with expression of telomere-related genes and telomere length in Bangladeshi individuals with a wide range of arsenic exposure through naturally contaminated drinking water.

Methods

We used linear regression models to estimate associations between urinary arsenic and array-based expression measures for 69 telomere related genes using mononuclear cell RNA samples from 1799 individuals. Association between arsenic exposure and a qP

SUBMITTER: Gao J 

PROVIDER: S-EPMC4264833 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature