Genome-wide association study of height-adjusted BMI in childhood identifies functional variant in ADCY3.

ABSTRACT:

Objective

Genome-wide association studies (GWAS) of BMI are mostly undertaken under the assumption that "kg/m(2) " is an index of weight fully adjusted for height, but in general this is not true. The aim here was to assess the contribution of common genetic variation to a adjusted version of that phenotype which appropriately accounts for covariation in height in children.

Methods

A GWAS of height-adjusted BMI (BMI[x] = weight/height(x) ), calculated to be uncorrelated with height, in 5809 participants (mean age 9.9 years) from the Avon Longitudinal Study of Parents and Children (ALSPAC) was performed.

Results

GWAS based on BMI[x] yielded marked differences in genomewide results profile. SNPs in ADCY3 (adenylate cyclase 3) were associated at genome-wide significance

SUBMITTER: Stergiakouli E 

PROVIDER: S-EPMC4265207 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature