Two birds with one stone: doing metabolomics with your proteomics kit.

ABSTRACT: Proteomic research facilities and laboratories are facing increasing demands for the integration of biological data from multiple '-OMICS' approaches. The aim to fully understand biological processes requires the integrated study of genomes, proteomes and metabolomes. While genomic and proteomic workflows are different, the study of the metabolome overlaps significantly with the latter, both in instrumentation and methodology. However, chemical diversity complicates an easy and direct access to the metabolome by mass spectrometry (MS). The present review provides an introduction into metabolomics workflows from the viewpoint of proteomic researchers. We compare the physicochemical properties of proteins and peptides with metabolites/small molecules to establish principle differences betwee

SUBMITTER: Fischer R 

PROVIDER: S-EPMC4265265 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature