Adherence to oral diabetes medications and glycemic control during and following breast cancer treatment.

ABSTRACT:

Objectives

We evaluated changes in oral diabetes mellitus medication adherence and persistence, as well as glycemic control for the year prior to breast cancer (BC) diagnosis (Year -1), during BC treatment, and in subsequent years.

Methods

Cohort study of 4216 women diagnosed with incident early stage (I and II) invasive BC from 1990-2008, enrolled in Group Health Cooperative. Adherence was measured in prevalent users at baseline (N = 509), during treatment, and 1-3 years post-diagnosis using medication possession ratio (MPR), % adherent (MPR ≥0.80) and discontinuation rates. Laboratory data on glycosylated hemoglobin (HbA1c ) was obtained for the corresponding periods.

Results

Compared with Year -1, mean MPR for metformin/sulfonylureas (0.86 vs 0.49, p < 0.001) and %

SUBMITTER: Calip GS 

PROVIDER: S-EPMC4265308 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature