De novo prediction of cis-regulatory elements and modules through integrative analysis of a large number of ChIP datasets.

ABSTRACT:

Background

In eukaryotes, transcriptional regulation is usually mediated by interactions of multiple transcription factors (TFs) with their respective specific cis-regulatory elements (CREs) in the so-called cis-regulatory modules (CRMs) in DNA. Although the knowledge of CREs and CRMs in a genome is crucial to elucidate gene regulatory networks and understand many important biological phenomena, little is known about the CREs and CRMs in most eukaryotic genomes due to the difficulty to characterize them by either computational or traditional experimental methods. However, the exponentially increasing number of TF binding location data produced by the recent wide adaptation of chromatin immunoprecipitation coupled with microarray hybridization (ChIP-chip) or high-throughput sequenci

SUBMITTER: Niu M 

PROVIDER: S-EPMC4265420 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature