Single particle tracking reveals biphasic transport during nanorod magnetophoresis through extracellular matrix.

ABSTRACT: Magnetic drug targeting has been proposed as a means of efficiently targeting drugs to tumors. However, the extracellular matrix (ECM) remains a significant barrier to long-range magnetophoretic transport through the tumor volume. While ensemble measurements of nanoparticle magnetophoresis have been reported, a single particle level understanding of magnetophoretic transport remains at large. We quantify nanorod magnetophoresis through ECM based on single particle observations. We find that smaller diameter particles achieve larger velocities through ECM despite experiencing smaller magnetic forces. Additionally, two interesting dynamics are elucidated. First, 18 nm diameter nanorods experience bimodal stick-slip motion through ECM during static field magnetophoresis, while similar bimodal

SUBMITTER: Mair LO 

PROVIDER: S-EPMC4265469 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature