Pharmacokinetics of prenylated hop phenols in women following oral administration of a standardized extract of hops.

ABSTRACT:

Scope

Women seeking alternatives to hormone-replacement therapy for menopausal symptoms often try botanical dietary supplements containing extracts of hops (Humulus lupulus L.). Hops contain 8-prenylnaringenin (8-PN), a potent phytoestrogen, the related flavanones 6-prenylnaringenin and isoxanthohumol (IX), and the prenylated chalcone xanthohumol (XN).

Methods and results

After chemically and biologically standardizing an extract of spent hops to these marker compounds, an escalating dose study was carried out in menopausal women to evaluate safety and pharmacokinetics. 8-PN, 6-prenylnaringenin, IX, and XN, sex hormones, and prothrombin time were determined in blood samples and/or 24 h urine samples. There was no effect on sex hormones or blood clotting. The maximum serum co

SUBMITTER: van Breemen RB 

PROVIDER: S-EPMC4265473 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature