Case-control study of diabetes-related genetic variants and pancreatic cancer risk in Japan.

ABSTRACT:

Aim

To examine whether diabetes-related genetic variants are associated with pancreatic cancer risk.

Methods

We genotyped 7 single-nucleotide polymorphisms (SNPs) in PPARG2 (rs1801282), ADIPOQ (rs1501299), ADRB3 (rs4994), KCNQ1 (rs2237895), KCNJ11 (rs5219), TCF7L2 (rs7903146), and CDKAL1 (rs2206734), and examined their associations with pancreatic cancer risk in a multi-institute case-control study including 360 cases and 400 controls in Japan. A self-administered questionnaire was used to collect detailed information on lifestyle factors. Genotyping was performed using Fluidigm SNPtype assays. Unconditional logistic regression methods were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between these diabetes-associated variants and

SUBMITTER: Kuruma S 

PROVIDER: S-EPMC4265605 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature