Association of open-angle glaucoma loci with incident glaucoma in the Blue Mountains Eye Study.

ABSTRACT:

Purpose

To determine if open-angle glaucoma (OAG)-associated single nucleotide polymorphisms (SNPs) are associated with incident glaucoma and if such genetic information is useful in OAG risk prediction.

Design

Case-control from within a population-based longitudinal study.

Methods

study population: Individuals aged over 49 years of age living in the Blue Mountains region west of Sydney and enrolled in the Blue Mountains Eye Study. observation: Cases for this sub-study (n = 67) developed incident OAG between baseline and 10-year visits, in either eye, while controls (n = 1919) had no evidence for OAG at any visit. All participants had an ocular examination and DNA genotyped for reported OAG risk SNPs. main outcome measure: Incident OAG.

Results

Two loci also kn

SUBMITTER: Burdon KP 

PROVIDER: S-EPMC4265734 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature