Optimization of drug-like properties of nonsteroidal glucocorticoid mimetics and identification of a clinical candidate.

ABSTRACT: A series of nonsteroidal "dissociated" glucocorticoid receptor agonists was optimized for drug-like properties such as cytochrome P450 inhibition, metabolic stability, aqueous solubility, and hERG ion channel inhibition. This effort culminated in the identification of the clinical candidate compound ( R )-39.

SUBMITTER: Harcken C 

PROVIDER: S-EPMC4265816 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature