Secreted frizzled-related protein 1 regulates adipose tissue expansion and is dysregulated in severe obesity.

ABSTRACT:

Aim

The Wnt/β-catenin signaling network offers potential targets to diagnose and uncouple obesity from its metabolic complications. In this study, we investigate the role of the Wnt antagonist, secreted frizzled-related protein 1 (SFRP1), in promoting adipogenesis in vitro and adipose tissue expansion in vivo.

Methods

We use a combination of human and murine, in vivo and in vitro models of adipogenesis, adipose tissue expansion and obesity-related metabolic syndrome to profile the involvement of SFRP1.

Results

SFRP1 is expressed in both murine and human mature adipocytes. The expression of SFRP1 is induced during in vitro adipogenesis, and SFRP1 is preferentially expressed in mature adipocytes in human adipose tissue. Constitutive ectopic expression of SFRP1 is proadi

SUBMITTER: Lagathu C 

PROVIDER: S-EPMC4266104 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature