Altered neural correlates of reward and loss processing during simulated slot-machine fMRI in pathological gambling and cocaine dependence.

ABSTRACT:

Background

Individuals with gambling or substance-use disorders exhibit similar functional alterations in reward circuitry suggestive of a shared underlying vulnerability in addictive disorders. Additional research into common and unique alterations in reward-processing in substance-related and non-substance-related addictions may identify neural factors that could be targeted in treatment development for these disorders.

Methods

To investigate contextual reward-processing in pathological gambling, a slot-machine fMRI task was performed by three groups (with pathological gambling, cocaine dependence and neither disorder; N = 24 each) to determine the extent to which two groups with addictions (non-substance-related and substance-related) showed similarities and differences w

SUBMITTER: Worhunsky PD 

PROVIDER: S-EPMC4266109 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature