Altered cortical thickness related to clinical severity but not the untreated disease duration in schizophrenia.

ABSTRACT: Although previous studies have reported deficits in the gray matter volume of schizophrenic patients, it remains unclear whether these deficits occur at the onset of the disease, before treatment, and whether they are progressive over the duration of untreated disease. Furthermore, the gray matter volume represents the combinations of cortical thickness and surface area; these features are believed to be influenced by different genetic factors. However, cortical thickness and surface area in antipsychotic-naive first-episode schizophrenic patients have seldom been investigated. Here, the cortical thicknesses and surface areas of 128 antipsychotic-naive first-episode schizophrenic patients were compared with 128 healthy controls. The patients exhibited significantly lower cortical thickness

SUBMITTER: Xiao Y 

PROVIDER: S-EPMC4266280 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature