Altered cortical expression of GABA-related genes in schizophrenia: illness progression vs developmental disturbance.

ABSTRACT:

Background

Schizophrenia is a neurodevelopmental disorder with altered expression of GABA-related genes in the prefrontal cortex (PFC). However, whether these gene expression abnormalities reflect disturbances in postnatal developmental processes before clinical onset or arise as a consequence of clinical illness remains unclear.

Methods

Expression levels for 7 GABA-related transcripts (vesicular GABA transporter [vGAT], GABA membrane transporter [GAT1], GABAA receptor subunit α1 [GABRA1] [novel in human and monkey cohorts], glutamic acid decarboxylase 67 [GAD67], parvalbumin, calretinin, and somatostatin [previously reported in human cohort, but not in monkey cohort]) were quantified in the PFC from 42 matched pairs of schizophrenia and comparison subjects and from 49 rhesu

SUBMITTER: Hoftman GD 

PROVIDER: S-EPMC4266281 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature