Schizophrenia and autism as contrasting minds: neural evidence for the hypo-hyper-intentionality hypothesis.

ABSTRACT: Both schizophrenia (SCZ) and autism spectrum disorder (ASD) are characterized by mentalizing problems and associated neural dysfunction of the social brain. However, the deficits in mental state attribution are somehow opposed: Whereas patients with SCZ tend to over-attribute intentions to agents and physical events ("hyper-intentionality"), patients with autism treat people as devoid of intentions ("hypo-intentionality"). Here we aimed to investigate whether this hypo-hyper-intentionality hypothesis can be supported by neural evidence during a mentalizing task. Using functional magnetic resonance imaging (fMRI), we investigated the neural responses and functional connectivity during reading others intention. Scanning was performed in 23 individuals with ASD, 18 with paranoid SCZ and 23 ge

SUBMITTER: Ciaramidaro A 

PROVIDER: S-EPMC4266299 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature