Sensitivity of quantitative sensory models to morphine analgesia in humans.

ABSTRACT:

Introduction

Opioid analgesia can be explored with quantitative sensory testing, but most investigations have used models of phasic pain, and such brief stimuli may be limited in the ability to faithfully simulate natural and clinical painful experiences. Therefore, identification of appropriate experimental pain models is critical for our understanding of opioid effects with the potential to improve treatment.

Objectives

The aim was to explore and compare various pain models to morphine analgesia in healthy volunteers.

Methods

The study was a double-blind, randomized, two-way crossover study. Thirty-nine healthy participants were included and received morphine 30 mg (2 mg/mL) as oral solution or placebo. To cover both tonic and phasic stimulations, a comprehensive mu

SUBMITTER: Olesen AE 

PROVIDER: S-EPMC4266386 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature