Prognostic phenotypic and genotypic factors associated with photodynamic therapy response in patients with age-related macular degeneration.

ABSTRACT:

Background

This study aimed to demonstrate the phenotypic and genotypic factors associated with photodynamic therapy (PDT) for age-related macular degeneration (AMD).

Methods

The study included 149 patients with exudative AMD treated by PDT. Eight phenotypic factors and ten genotypic factors for three single nucleotide polymorphisms (SNPs; rs800292, rs1061170, rs1410996) in the complement factor H (CFH) gene, rs 11200638-SNP in the high temperature requirement A-1 (HTRA1) gene, two SNPs (rs699947, rs2010963) in the vascular endothelial growth factor (VEGF) gene, and four SNPs (rs12948385, rs12150053, rs9913583, rs1136287) in the pigment epithelium-derived factor (PEDF) gene were evaluated.

Results

A significant association with best-corrected visual acuity change was

SUBMITTER: Tsuchihashi T 

PROVIDER: S-EPMC4266424 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature