Gold-Coated Fe₃O₄ Nanoroses with Five Unique Functions for Cancer Cell Targeting, Imaging and Therapy.

ABSTRACT: The development of nanomaterials that combine diagnostic and therapeutic functions within a single nanoplatform is extremely important for molecular medicine. Molecular imaging with simultaneous diagnosis and therapy will provide the multimodality needed for accurate diagnosis and targeted therapy. Here, we demonstrate gold-coated iron oxide (Fe₃O₄@Au) nanoroses with five distinct functions, which integrate aptamer-based targeting, magnetic resonance imaging (MRI), optical imaging, photothermal therapy and chemotherapy into one single probe. The inner Fe₃O₄ core functions as an MRI agent, while the photothermal effect is achieved through near-infrared absorption by the gold shell, causing a rapid rise in temperature and also resulting in a facili

SUBMITTER: Li C 

PROVIDER: S-EPMC4266531 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature