Pharmacogenomics of 17-alpha hydroxyprogesterone caproate for recurrent preterm birth prevention.

ABSTRACT:

Objective

We hypothesized that genetic variation affects responsiveness to 17-alpha hydroxyprogesterone caproate (17P) for recurrent preterm birth prevention.

Study design

Women of European ancestry with ≥1 spontaneous singleton preterm birth at <34 weeks' gestation who received 17P were recruited prospectively and classified as a 17P responder or nonresponder by the difference in delivery gestational age between 17P-treated and -untreated pregnancies. Samples underwent whole exome sequencing. Coding variants were compared between responders and nonresponders with the use of the Variant Annotation, Analysis, and Search Tool (VAAST), which is a probabilistic search tool for the identification of disease-causing variants, and were compared with a Kyoto Encyclopedia of Genes an

SUBMITTER: Manuck TA 

PROVIDER: S-EPMC4266558 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature