TT genotype of GNAS1 T393C polymorphism predicts better outcome of advanced non-small cell lung cancer patients.

ABSTRACT:

Aim

To evaluate the potential prognostic value of GNAS1 T393C polymorphism in advanced non-small cell lung cancer.

Methods

We extracted genomic DNA from the peripheral blood leucocytes of 94 patients with advanced non-small cell lung cancer. Quantitative real-time polymerase chain reaction was used to determine the allelic discrimination. The correlation between genotype and overall survival was evaluated using the multivariate analysis and Kaplan-Meier approach.

Results

Thirty-eight out of 94 (40%) patients displayed a TT genotype, 29 out of 94 (31%) a CT genotype and 27 out of 94 (29%) a CC genotype. The median survival of TT (25 mo) genotype carriers was longer than CT (12 mo) or CC (8 mo) genotype carriers. The favorable TT genotype predicted better overall surviv

SUBMITTER: Gong HY 

PROVIDER: S-EPMC4266817 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature