Habitual sleep duration is associated with BMI and macronutrient intake and may be modified by CLOCK genetic variants.

ABSTRACT:

Background

Short sleep duration has been associated with greater risks of obesity, hypertension, diabetes, and cardiovascular disease. Also, common genetic variants in the human Circadian Locomotor Output Cycles Kaput (CLOCK) show associations with ghrelin and total energy intake.

Objectives

We examined associations between habitual sleep duration, body mass index (BMI), and macronutrient intake and assessed whether CLOCK variants modify these associations.

Design

We conducted inverse-variance weighted, fixed-effect meta-analyses of results of adjusted associations of sleep duration and BMI and macronutrient intake as percentages of total energy as well as interactions with CLOCK variants from 9 cohort studies including up to 14,906 participants of European descent fr

SUBMITTER: Dashti HS 

PROVIDER: S-EPMC4266883 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature