Variation in the SLC23A1 gene does not influence cardiometabolic outcomes to the extent expected given its association with L-ascorbic acid.

ABSTRACT:

Background

Observational studies showed that circulating L-ascorbic acid (vitamin C) is inversely associated with cardiometabolic traits. However, these studies were susceptible to confounding and reverse causation.

Objectives

We assessed the relation between L-ascorbic acid and 10 cardiometabolic traits by using a single nucleotide polymorphism in the solute carrier family 23 member 1 (SLC23A1) gene (rs33972313) associated with circulating L-ascorbic acid concentrations. The observed association between rs33972313 and cardiometabolic outcomes was compared with that expected given the rs33972313-L-ascorbic acid and L-ascorbic acid-outcome associations.

Design

A meta-analysis was performed in the following 5 independent studies: the British Women's Heart and Health Stu

SUBMITTER: Wade KH 

PROVIDER: S-EPMC4266888 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature