Invasive breast carcinoma cells from patients exhibit MenaINV- and macrophage-dependent transendothelial migration.

ABSTRACT: Metastasis is a complex, multistep process of cancer progression that has few treatment options. A critical event is the invasion of cancer cells into blood vessels (intravasation), through which cancer cells disseminate to distant organs. Breast cancer cells with increased abundance of Mena [an epidermal growth factor (EGF)-responsive cell migration protein] are present with macrophages at sites of intravasation, called TMEM sites (for tumor microenvironment of metastasis), in patient tumor samples. Furthermore, the density of these intravasation sites correlates with metastatic risk in patients. We found that intravasation of breast cancer cells may be prevented by blocking the signaling between cancer cells and macrophages. We obtained invasive breast ductal carcinoma cells of various s

SUBMITTER: Pignatelli J 

PROVIDER: S-EPMC4266931 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature