Clinical course of light-chain smouldering multiple myeloma (idiopathic Bence Jones proteinuria): a retrospective cohort study.

ABSTRACT:

Background

Bence Jones proteinuria is a disorder that is defined by the excretion of monoclonal light-chain protein. About 15-20% of patients with multiple myeloma secrete monoclonal light chains only, without expression of the normal immunoglobulin heavy chain, which constitutes light-chain multiple myeloma. The definition, prevalence, and progression of these premalignant phases of light-chain multiple myeloma have not been fully characterised. We aimed to identify a subset of patients with idiopathic Bence Jones proteinuria who had a high risk of progression to light-chain multiple myeloma analogous to that seen in patients with smouldering multiple myeloma.

Methods

In this retrospective cohort study, we studied all patients seen at the Mayo Clinic (Rochester, MN, USA) wi

SUBMITTER: Kyle RA 

PROVIDER: S-EPMC4266993 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature