Transplantation of human fetal biliary tree stem/progenitor cells into two patients with advanced liver cirrhosis.

ABSTRACT:

Background

Efforts to identify cell sources and approaches for cell therapy of liver diseases are ongoing, taking into consideration the limits recognized for adult liver tissue and for other forms of stem cells. In the present study, we described the first procedure of via hepatic artery transplantation of human fetal biliary tree stem cells in patients with advanced cirrhosis.

Methods

The cells were immune-sorted from human fetal biliary tree by protocols in accordance with current good manufacturing practice (cGMP) and extensively characterized. Two patients with advanced liver cirrhosis (Child-Pugh C) have been submitted to the procedure and observed through a 12 months follow-up.

Results

The resulting procedure was found absolutely safe. Immuno-suppressants were

SUBMITTER: Cardinale V 

PROVIDER: S-EPMC4267130 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature