Progressive neurodegeneration after experimental brain trauma: association with chronic microglial activation.

ABSTRACT: Recent clinical studies indicate that traumatic brain injury (TBI) produces chronic and progressive neurodegenerative changes leading to late neurologic dysfunction, but little is known about the mechanisms underlying such changes. Microglial-mediated neuroinflammationis an important secondary injury mechanism after TBI. In human studies, microglial activation has been found to persist for many years after the initial brain trauma, particularly after moderate to severe TBI. In the present study, adult C57Bl/6 mice were subjected to single moderate-level controlled cortical impact and were followed up by longitudinal T2-weighted magnetic resonance imaging in combination with stereologic histologic assessment of lesion volume expansion, neuronal loss, and microglial activation for up to 1 ye

SUBMITTER: Loane DJ 

PROVIDER: S-EPMC4267248 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature