Arterial stiffness and β-amyloid progression in nondemented elderly adults.

ABSTRACT:

Importance

Recent studies show that cerebral β-amyloid (Aβ) deposition is associated with blood pressure and measures of arterial stiffness in nondemented individuals.

Objective

To examine the association between measures of arterial stiffness and change in Aβ deposition over time.

Design, setting, and participants

Deposition of Aβ was determined in a longitudinal observational study of aging by positron emission tomography using the Pittsburgh compound B twice 2 years apart in 81 nondemented individuals 83 years and older. Arterial stiffness was measured with a noninvasive and automated waveform analyzer at the time closest to the second positron emission tomography scan. All measures were performed under standardized conditions. Pulse wave velocity (PWV) was measure

SUBMITTER: Hughes TM 

PROVIDER: S-EPMC4267249 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature