Tigecycline suppresses toxin A and B production and sporulation in Clostridium difficile.

ABSTRACT:

Background

Clostridium difficile infection (CDI) is mediated by potent extracellular toxins and is spread largely via bacterial spores. We and others have shown that some antibiotics stimulate C. difficile toxin production in a strain-specific manner; however, the effects of newer anti-C. difficile antibiotics on this process remain to be investigated.

Methods

The effects of the protein synthesis inhibitor tigecycline on sporulation and toxin A and toxin B production were compared in historical (strain 9689) and hypervirulent BI/NAP1/027 (strain 5325) isolates of C. difficile in vitro.

Results

Tigecycline at 1/4× MIC stimulated an increased and earlier toxin A and/or B gene expression in both the historical and the hypervirulent strains, although a commensurate increa

SUBMITTER: Aldape MJ 

PROVIDER: S-EPMC4267498 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature