Nevirapine or efavirenz for tuberculosis and HIV coinfected patients: exposure and virological failure relationship.

ABSTRACT:

Objectives

We describe nevirapine and efavirenz exposure on and off tuberculosis treatment and consequences for virological efficacy and tolerance in patients included in the ANRS 12146/12214-CARINEMO trial.

Methods

Participants were randomly selected to receive either nevirapine at 200 mg twice daily (n = 256) or efavirenz at 600 mg daily (n = 270), both combined with two nucleoside analogues. Blood samples were drawn 12 h after nevirapine or efavirenz administration, while on tuberculosis treatment and after tuberculosis treatment discontinuation. In 62 participants, samples taken 12 h after drug administration were drawn weekly for the first month of ART. Sixteen participants participated in an extensive pharmacokinetic study of nevirapine. Concentrations were compared wi

SUBMITTER: Bhatt NB 

PROVIDER: S-EPMC4267502 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature