A putatively functional polymorphism in the HTR2C gene is associated with depressive symptoms in white females reporting significant life stress.

ABSTRACT: Psychosocial stress is well known to be positively associated with subsequent depressive symptoms. Cortisol response to stress may be one of a number of biological mechanisms that links psychological stress to depressive symptoms, although the precise causal pathway remains unclear. Activity of the x-linked serotonin 5-HTR2C receptor has also been shown to be associated with depression and with clinical response to antidepressant medications. We recently demonstrated that variation in a single nucleotide polymorphism on the HTR2C gene, rs6318 (Ser23Cys), is associated with different cortisol release and short-term changes in affect in response to a series of stress tasks in the laboratory. Based on this observation, we decided to examine whether rs6318 might moderate the association betwee

SUBMITTER: Brummett BH 

PROVIDER: S-EPMC4267787 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature