Vertical signalling involves transmission of Hox information from gastrula mesoderm to neurectoderm.

ABSTRACT: Development and patterning of neural tissue in the vertebrate embryo involves a set of molecules and processes whose relationships are not fully understood. Classical embryology revealed a remarkable phenomenon known as vertical signalling, a gastrulation stage mechanism that copies anterior-posterior positional information from mesoderm to prospective neural tissue. Vertical signalling mediates unambiguous copying of complex information from one tissue layer to another. In this study, we report an investigation of this process in recombinates of mesoderm and ectoderm from gastrulae of Xenopus laevis. Our results show that copying of positional information involves non cell autonomous autoregulation of particular Hox genes whose expression is copied from mesoderm to neurectoderm in the gas

SUBMITTER: Bardine N 

PROVIDER: S-EPMC4267835 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature